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In this particular conformation, HGF II binding strengthens the interaction between HGF I and c-MET II and thereby stabilizes the entire c-MET I/HGF I/c-MET II complex (Fig

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Patients with controlled uric acid level and doing well on allopurinol would seem to have no reason to switch to this new agent, in view of allopurinol's lower cost and 40-year history of an overall very good safety record (see "Allopurinol" discussion above)